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TBS Contract research services
CRO services: Bone-quality endpoints for your clinical trials
Partner with the team behind the global standard in bone microarchitecture. We bring validated TBS® analysis and central DXA reading to studies where bone is an efficacy or safety signal.
Why partner with us
A sensitive, validated bone endpoint — and the team that built it
Bone is increasingly a factor in trials far beyond osteoporosis: Oncology therapies, anti-diabetics, glucocorticoids and endocrine agents can all move bone quality before they move bone density. Trabecular Bone Score® (TBS®) captures that structural change, often earlier and more sensitively than BMD alone.
As the developer of TBS®, Medimaps offers sponsors a rare combination: A regulatory-grade analytical method, centralised image handling, and direct access to the scientific team whose work is cited across international guidelines.
35+
guidelines reference TBS®1
1,600+
peer-reviewed TBS® publications1
45
M
TBS® evaluations performed annually1
90+
countries with clinical deployments1
Ready for multi-region trials. MDSAP certification means our quality system has already passed a single audit recognised by five regulators: FDA, Health Canada, TGA, ANVISA and PMDA.
What we offer
End-to-end bone assessment for your study
From protocol design through to a clean, analysis-ready dataset.
Central TBS & DXA analysis
Standardised, blinded central reading across all your sites, removing inter-site variability from your bone data.
Bone-quality endpoints
TBS® as a primary, secondary or safety endpoint, capturing microarchitectural change BMD can miss.
Study design support
Protocol and statistical input on where and how bone-quality measures strengthen your evidence.
Regulatory-grade data
Documentation and QC aligned to an ISO 13485 quality system, ready for submission scrutiny.
Scientific advisory
Direct access to the research team behind TBS® for scientific rationale, publications and expert input.
Analysis & reporting
Clean, analysis-ready datasets and clear reporting, delivered to your biostatistics team on schedule.
The scientific case
Why bone quality belongs in your protocol
- Detects change earlier: Microarchitectural decline can precede measurable density loss — a more responsive signal over a trial's timeline.
- Independent of BMD: TBS® adds information density doesn't capture, strengthening the completeness of your bone-safety story.
- From existing scans: Derived from standard lumbar-spine DXA; no additional imaging modality or patient burden to add to your protocol.
Same scan
TBS® is computed from the very DXA image already acquired for BMD — a second, structural endpoint at no added patient dose.
Applicable across therapeutic areas where bone is an efficacy or safety consideration: Oncology, Endocrinology, Diabetes, Rheumatology, women's health, and more.
TBS · Trabecular Bone Score
The global standard in bone microarchitecture assessment
TBS® is a patented, validated analytical index derived from routine DXA scans, revealing the internal structural quality of bone that BMD cannot measure. More than a decade of peer-reviewed research underpins its clinical use worldwide.
Clinically proven
TBS evidence keeps growing
2026 · Diagnostics
Beyond DXA: Trabecular Bone Score, Quantitative Ultrasound and Bone Turnover Markers for Morphometric Vertebral Fracture Assessment in People Living with HIV
Razvan, D.V., Rosca, O., et al.
2024 · The Journal of Clinical Endocrinology and Metabolism
Trabecular Bone Score as a Marker of Skeletal Fragility Across the Spectrum of Chronic Kidney Disease: A Systematic Review and Meta-analysis
Bioletto, F., Barale, M., et al.
2023 · Osteoporosis International
Long-term Effect of Denosumab on Bone Microarchitecture as Assessed by Tissue Thickness-adjusted Trabecular Bone Score in Postmenopausal Women with Osteoporosis: Results from FREEDOM and its Open-label Extension
Hans, D., McDermott, M., et al.
How it works
A straightforward engagement
1
Scope
We discuss your study, endpoints, and timelines under NDA
2
Design
We align on the bone-assessment plan and deliverables
1
Deliver
Central reading and analysis run across your sites as data arrives
2
Report
Analysis-ready datasets and reporting handed to your team
Start a conversation
Tell us about your study
Send us a note and our scientific team will get back to you to explore whether TBS® fits your programme.
- Pharmaceutical and biotech sponsors
- Contract research organisations
- Academic and investigator-led trials
- Medical-affairs and clinical-development teams
Talk to our clinical team and we'll point you to the right solution for your setting.
References (1)
1. Medimaps Group (2026) Internal data (data on file).